Ioannis (Yannis) Androulakis

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  Circadian rhythms and host defenses
  Ioannis (Yannis) Androulakis
  In this talk I will discuss key ideas emphasizing the central role circadian dynamics, and their misalignment, play in orchestrating and coordinating defense mechanisms. Emphasis will be given on the neuroendocrine circadian clock cell cycle interactions. We will discuss how the intertwined relations and dynamic characteristics of each component interact with each other and how environmental and pharmacologic interventions alter these relations providing relative advantages and disadvantages to the host in response to external stress. The emerging dynamics plays a central role in the ways hosts mount, compromise or enhance defense responses during interactions with pathogens.